Variation in CDKAL1 Gene Is Associated With Therapeutic Response to Sulphonylureas
نویسندگان
چکیده
منابع مشابه
Variation in KCNQ1 is associated with therapeutic response to sulphonylureas
BACKGROUND We aimed to analyse quantitative effects of treatment with sulphonylurea in addition to metformin on parameters of glycemic control in relation to KCNQ1 genotypes, and to identify factors predictive for the response to sulphonylurea treatment. MATERIAL/METHODS Effect of 6-month sulphonylurea therapy in addition to metformin on glycemic control according to KCNQ1 genotypes was evalu...
متن کاملVariation in the CDKAL1 gene is associated with the titer of antibodies to GAD.
G enome-wide association studies have described new diabetes susceptibility genes including TCF7L2, CDKAL1, HHEX, SLC30A8, CDKN2A/B, and IGF2BP2 (1). Most of these novel risk loci are associated with impaired -cell function (2). Impaired -cell function due to autoimmune processes plays a role in the pathogenesis of type 1A diabetes and latent autoimmune diabetes in adults. Therefore, it is conc...
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Background: CCL22/MDC is a CC chemokine with a critical role in regulation of the immune balance in physiological condition. CCL22/CCR-4 ligation has been documented to participate in the migration of regulatory T (Treg) cells and Th2 lymphocytes to the site of breast tumors; circumstances that are known to be associated with poor prognosis. Objective: To investigate the association of a single...
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Infection with the hepatitis C virus (HCV) is a major cause of chronic liver diseases and hepatocellular carcinoma worldwide, and thus represents a significant public health problem. The type I interferon (IFN), IFNα, has been successful in treating HCV-infected patients, but current IFN-based treatment regimens for HCV have suboptimal efficacy, and relatively little is known about why IFN ther...
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Background: Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. Methods: The variants were investig...
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ژورنال
عنوان ژورنال: Physiological Research
سال: 2012
ISSN: 1802-9973,0862-8408
DOI: 10.33549/physiolres.932228